prognostic signature
Tumor Gene Expression Signature Linked to Chemotherapy Response in Colon Cancer Cases
Based on hundreds of stage II and III colon cancer samples, researchers uncovered and validated a 10-gene signature linked to adjuvant chemotherapy response.
Investigators last month published early results, which they believe have set a solid foundation for the independent value of their novel signature.
UK's NICE Expands Tumor Profiling Recommendations for Guiding Adjuvant Chemo in Early Breast Cancer
Previously, NICE recommended EndoPredict, Prosigna, and Oncotype DX for node-negative breast cancer only, but the new guidance includes lymph node-positive disease.
Trial Failure Raises Questions About MRD Testing Utility, but Prognostic Evidence Remains Strong
Presentations at last week's ASCO GI meeting highlighted the ongoing generation of promising data for ctDNA-based minimal residual disease testing despite recent missteps.
Agendia Studying Effect of Forgoing Chemo in Early-Stage MammaPrint Low-Risk Breast Cancer Patients
In the PROOFS trial, researchers hope to definitively show that MammaPrint low-risk patients can temporarily suppress their ovaries and forgo chemotherapy without negative outcomes.