genotyping
COVID-19 Protection Provided by HLA Genetic Variant, Study Suggests
Using data from bone marrow registry participants, researchers found an HLA variant linked to symptom-free SARS-CoV-2 infection and better immune cell responses.
Association for Molecular Pathology Releases CYP3A4 and CYP3A5 Genotyping Recommendations
The AMP Pharmacogenetics Working Group recommended four alleles for a minimum panel (tier 1) and one allele for an extended panel (tier 2).
PGx-Guided Dosing Can Lead to Faster Therapeutic Blood Levels of Antidepressants
A randomized controlled trial compared cytochrome P450 genotype-based dosing of tricyclic antidepressants to usual care among patients with depression.
Asthma Risk Heightened by Genetic Predisposition, Poor Sleep Patterns
Researchers found that favorable sleep patterns can dial down asthma risk in individuals at high polygenic risk, while poor sleep patterns boost prevalence of the condition.
The three-year Ubiquitous Pharmacogenomics Consortium's PREPARE study enrolled nearly 7,000 patients in seven European countries.