PALB2
Their study showed that DCIS patients with pathogenic variants in BRCA1/2 and PALB2 had a higher risk of developing invasive breast cancer than those without.
Healthy Nevada Researchers Consider Impact of Low Genetic Breast Cancer Risk on Screening Guidelines
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Identifying a low genetic risk group could more precisely inform when patients should start mammograms and other preventive practices, a study suggests.
SABCS Studies Explore Germline Mutations' Varied Effects on Breast Cancer Risk, Survival Outcomes
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Researchers examine the interplay of germline cancer risk mutations and somatic mutations, and how surgery type and contraceptives impact breast cancer risk.
Next-Generation AstraZeneca PARP1 Inhibitor Shows Activity in Multiple Cancers at Variety of Doses
Early data on AZD5305 showed it is highly tolerable and suggested it may be amenable to combination and prevention strategies.
Genetic Testing Challenges in Oncology: Muddled Reporting, Interpretation of PALB2 VUS
A woman is sent for pancreatic cancer screening based on testing from a lab that refuses to share technical data and a doctor's misinterpretation of a VUS as pathogenic.