drug resistance
Focus on Primary Resistance May Improve KRAS Inhibitor Strategies in Colorectal, Pancreatic Cancer
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The presence of primary resistance and KRAS G12C co-mutations may explain limited single-agent efficacy of marketed KRAS inhibitors, a recent study suggests.
Researchers have flagged 99 genes related to muscle contractility related to spontaneous preterm birth, along with nine potentially therapeutic drugs that target them.
Research Characterizes Immunotherapy Resistance in NSCLC, Suggests Pathways to Re-Sensitize Tumors
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The researchers identified a range of genomic and immune changes after immunotherapy that were potentially therapeutically targetable.
AstraZeneca Partners With Turbine to Identify Treatment Resistance in Blood Cancers
Turbine will use its machine learning-enabled cell simulation platform to identify mechanisms of therapy resistance.
Researchers conducted a trial that tested the activity of anti-SHP2 monotherapy and personalized combination regimens across different genetically altered tumor types.