Improvement of Formalin-Fixed Paraffin-Embedded Reference Materials for Molecular Analyses
Although some forms of precision medicine have existed for decades, next-generation sequencing (NGS) of tumors has yielded a plethora of mutations that inform clinical care. It is not uncommon for commercial NGS-based cancer gene panels to target more than 500 genes with several of those serving as biomarkers for therapeutic decisions. Beyond some of the common driver mutations, the acquisition of reference materials that contain even some of the mutations desired for assay optimization, validation, and monitoring is difficult.
This scientific poster from LGC SeraCare presents a new approach to FFPE reference materials, designed to ensure more accurate and reproducible results in NGS-based assays.