Precision Oncology Resources: Webinars

The landscape of drug discovery is rapidly evolving, driven by the need for more predictive and complex models that closely mimic human tissues. In this webinar, April Kloxin of the University of Delaware will discuss the application of advanced cell culture models developed through Inventia’s Rastrum platform, which enables the creation of complex in vitro tissue structures that replicate the cellular microenvironment. This tool enhances the investigation of disease mechanisms and the testing of therapeutic interventions with greater relevance to human biology.

Kloxin's research focuses on designing dynamic biomaterials that can be modified in real time to probe how specific environmental signals impact cell behavior, offering new insights into tissue repair, regeneration, and disease progression.

Key topics include:

• Overview of dynamic biomaterials and their applications.
• Insights into the role of the Rastrum platform in drug discovery.
• The impact of 3D cell models on understanding disease and regeneration.
• Collaborative approaches for tailored research solutions.

This presentation will highlight the potential of these cell culture models in developing therapies and improving patient outcomes.

In this webinar, Marcela Mazo Canola from UT Health San Antonio will join Heidi Ko and Kyle Strickland from Labcorp Oncology Medical Affairs to discuss patient cases in which biomarker testing contributed to tailored treatment strategies in the setting of metastatic breast cancer.

This session will highlight two clinical cases of metastatic hormone receptor-positive (HR+), HER2-negative breast cancer: one with a PIK3CA H1047R mutation and the other with an AKT1 L52R mutation. The team will discuss pivotal clinical trials that led to targeted therapies for these biomarkers, discuss key side-effect profiles, and share insights on testing workflows to optimize biomarker-guided therapy in HR+ breast cancer.

overview

Further details coming soon!

This event, part of the Precision Medicine Leaders’ Summit conference series and developed in partnership with the University of Pennsylvania Institute for Biomedical Informatics, took place June 25 - 26, 2024

The conference explored how multiomics methods are advancing precision medicine in a range of human disease areas.

Recent advances in multiomic approaches — including genomics, transcriptomics, epigenomics, proteomics, and metabolomics — enable a more comprehensive picture of disease biology. This promises to accelerate the development of precision medicine, but also presents challenges for researchers, clinicians, and health systems struggling to integrate disparate data sources into a cohesive clinical strategy.

Multiomics in Precision Medicine 2024 highlighted best practices, trends, and strategies from experts who are successfully implementing a range of omics approaches to advance molecularly informed medicine.

Further details coming soon!