Seattle Children's Studying CAR T-Cell Therapy Targeting Four Brain Cancer Antigens at Once
The Phase I BrainChild-04 trial will enroll pediatric, teen, and young adult patients with brain or central nervous system tumors.
Lynparza, Ceralasertib Combo Trial Provides Clues on Biomarkers of Response in Pediatric Cancer
In the tumor-agnostic study, pediatric patients with 11q loss and other alterations associated with replication stress benefited from the dual PARP-ATR inhibitor treatment.
Transcriptomic Classification of Pediatric Cancers Shows Potential to Improve Clinical Diagnoses
In a new paper, computational biologists at Toronto's Hospital for Sick Children described their atlas of childhood cancer subtypes and a corresponding search tool.
Baylor Team Aims to Identify Chemo Toxicity Biomarkers in Latino Pediatric Leukemia Patients
The CPRIT-funded study will examine clinical and genomic data from more than 2,000 Latino patients with acute lymphoblastic leukemia treated with high-dose chemo.
Novartis Nets FDA Approval for Tafinlar-Mekinist in Pediatric Low-Grade Glioma
Regulators approved Novartis' BRAF/MEK inhibitor combo for kids whose tumors harbor BRAF V600Emutations and simultaneously approved a new liquid form of the treatment.