Tissue-Based Drug Screening Platform Shows Potential to Improve Precision Brain Tumor Treatment
In a study by UNC researchers, all brain tumor samples grown on rat brain slices engrafted successfully and retained significant genetic similarity to the parent tumor.
Seattle Children's Studying CAR T-Cell Therapy Targeting Four Brain Cancer Antigens at Once
The Phase I BrainChild-04 trial will enroll pediatric, teen, and young adult patients with brain or central nervous system tumors.
DeepGlioma has shown it can classify brain tumors on the spot during surgery, and experts believe the AI-based imaging system can be useful for informing precision care.
The therapy, dubbed IGV-001, involves patients' own glioblastoma cells mixed with an antisense drug and implanted into the abdomen in dime-sized plastic chambers.
Adults with BRAF-mutated glioma have higher-grade tumors and decreased survival compared to children but can still benefit from targeted therapies.