Alison Kanski

Articles Authored by Alison Kanski
The researchers found biomarkers of macrophage activity and immune activity were associated with resistance and response to Opdivo plus Cabometyx.
Focus on Primary Resistance May Improve KRAS Inhibitor Strategies in Colorectal, Pancreatic Cancer
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The presence of primary resistance and KRAS G12C co-mutations may explain limited single-agent efficacy of marketed KRAS inhibitors, a recent study suggests.
Can Karyopharm's Blood Cancer Drug Xpovio Be an Option in KRAS-Mutant, TP53 Wild-Type Lung Cancer?
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In a recent trial, researchers found that Xpovio plus chemo had activity in NSCLC patients with KRAS mutations other than G12C.

Real-World Studies Aim to Optimize Treatment Sequence for Novartis' Pluvicto in Prostate Cancer
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Researchers explored how Pluvicto is used in the community and academic settings and when given by oncologists or urologists.
More Precise Response Markers Needed for Enhertu Amid HER2 Biomarker Disruption, Researchers Say
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By analyzing ERBB2 mRNA expression data, researchers identified a group of HER2-negative patients with poor outcomes and potential markers of treatment resistance.
Precision Medicine Supporters Worry About NIH Indirect Rate Cut's Impact on Advances, Workforce
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Researchers have been "making great inroads" in precision medicine, and a 15 percent cap on indirect costs could quash the momentum, experts worry.

Intravenous Opdivo, with $2.48 billion in sales, topped the list of precision oncology products in BMS's growth portfolio.

Amgen Reports More Than $2B in Oncology Revenues in Q4
Sales of the firm's bispecific T-cell engager Blincyto increased more than 50 percent from the fourth quarter of 2023 to 2024.
Pfizer Reports 27 Percent Oncology Growth in Q4, Touts Progress in ADC and Breast Cancer Trials
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The firm recorded Q4 oncology revenues of $4.06 billion compared to $3.19 billion in the same period in 2023.

Opdivo, Yervoy Outperform Single-Agent Immunotherapy in First-Line MSI-High, dMMR Colorectal Cancer
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Data presented at the ASCO Gastrointestinal Cancers Symposium showed the regimen may be a new option, but it comes with more treatment and financial toxicity.